Course: Structural analysis of biomolecules

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Course title Structural analysis of biomolecules
Course code AFC/SAB
Organizational form of instruction Lecture
Level of course Master
Year of study not specified
Semester Summer
Number of ECTS credits 3
Language of instruction Czech
Status of course Optional
Form of instruction Face-to-face
Work placements This is not an internship
Recommended optional programme components None
  • Čajan Michal, doc. RNDr. Ph.D.
Course content
1. Chemical bond and its properties. 2. Non-covalent interactions - van der Waals interactions, hydrogen bond. 3. Molecular structure - constitution, configuration, conformation. 4. Proteins, nucleid acids, saccharides, lipides - composition and basic structural features. 5. Proteins, nucleid acids, saccharides, lipides - occurence and roles in organisms. 6. Factors determining 3D biomolecular strucutre - structure propeties relationships. 7. Separation and isolation of biomacromolecules. 8. Biomolecular crystallography. 9. Biomolecular NMR. 10. Biomolecular mass spectrometry. 11. Theoretical methods in biomacromolecular structure investigation. 12. Basic protein engineering.

Learning activities and teaching methods
Monologic Lecture(Interpretation, Training), Work with Text (with Book, Textbook)
  • Homework for Teaching - 50 hours per semester
  • Preparation for the Exam - 50 hours per semester
  • Attendace - 26 hours per semester
Learning outcomes
Knowledge of issues presented within basic courses of general, physical, organic chemistry and biochemistry. Basic knowledge of principles of physico-chemical methods for atoms and molecules structure and properties analysis.

Assessment methods and criteria
Oral exam

Recommended literature
  • & Chance, M. (2008). Mass spectrometry analysis for protein-protein interactions and dynamics. Hoboken, N.J: Wiley.
  • Evans, J. N. S. (1995). Biomolecular NMR spectroscopy. Oxford: Oxford University Press.
  • Lipton, M. S., & Paša-Tolić, L. (2009). Mass spectrometry of proteins and peptides: methods and protocols. [New York]: Humana Press.
  • Malinowski B. (2007). Sex a represe v divošské společnosti. Praha: Slon.
  • Rupp, B. (2010). Biomolecular crystallography: principles, practice, and application to structural biology. New York, N.Y: Garland Science.
  • Seader, J. D., Henley, E. J., & Roper, K. D. (2011). Separation process principles: chemical and biochemical operations. Hoboken, N.J: John Wiley & Sons.
  • Sheehan, D. (2000). Physical biochemistry: principles and applications. Chichester: John Wiley and Sons.
  • Tinoco, I., Sauer, K., & Wang, J. C. (1985). Physical chemistry: principles and applications in biological sciences. Englewood Cliffs: Prentice-Hall.

Study plans that include the course
Faculty Study plan (Version) Branch of study Category Recommended year of study Recommended semester
Faculty of Science Teaching Training in Chemistry for Secondary Schools (2015) Pedagogy, teacher training and social care - Summer
Faculty of Science Bioinorganic Chemistry (1) Chemistry courses - Summer
Faculty of Science Inorganic Chemistry (2015) Chemistry courses - Summer
Faculty of Science Molecular and Cell Biology (2015) Biology courses - Summer