Course: Drug Metabolism

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Course title Drug Metabolism
Course code FAR/VCB31
Organizational form of instruction Seminar
Level of course Master
Year of study not specified
Semester Summer
Number of ECTS credits 2
Language of instruction Czech
Status of course Optional
Form of instruction Face-to-face
Work placements This is not an internship
Recommended optional programme components None
Course availability The course is available to visiting students
Lecturer(s)
  • Anzenbacher Pavel, prof. RNDr. DrSc.
Course content
Phases of drug metabolism. Main reactions of the first and second phase.Cytochromes P450 as the most important enzymes of drug metabolism. Genomics and proteomics of P450. Gene superfamily of P450. Function of P450 in drug metabolism, enzyme induction and inhibition. Gene polymorphism. Drug interactions, types. Clinically relevant pharmacokinetic drug interactions.

Learning activities and teaching methods
Lecture, Dialogic Lecture (Discussion, Dialog, Brainstorming), Work with Text (with Book, Textbook)
Learning outcomes
Students learn about the metabolism of the drugs, about cytochromes P450 which are responsible for metabolism of more than three fourth of drugs with known metabolic pathways. Students should be familiar also with the drug interactions at the level of drug metabolism (competition, inhibition or induction of P450 enzymes).
Students should be familiar with the metabolism and interaction of the main groups of drugs.
Prerequisites
Completion all of prescribed exams.

Assessment methods and criteria
Analysis of Activities ( Technical works), Dialog

Participation in all seminars.
Recommended literature
  • Katzung, B. G. (2006). Základní a klinická farmakologie. Jihočany: HaH Vyšehradská.


Study plans that include the course
Faculty Study plan (Version) Branch of study Category Recommended year of study Recommended semester
Faculty of Medicine and Dentistry General Medicine (2011) Medical sciences 4 Summer
Faculty of Medicine and Dentistry General Medicine (2015) Medical sciences 4 Summer
Faculty of Medicine and Dentistry General Medicine (2014) Medical sciences 4 Summer
Faculty of Medicine and Dentistry General Medicine (2012) Medical sciences 4 Summer