|Course title||Drug Metabolism|
|Organizational form of instruction||Seminar|
|Level of course||Master|
|Year of study||not specified|
|Number of ECTS credits||2|
|Language of instruction||Czech|
|Status of course||Optional|
|Form of instruction||Face-to-face|
|Work placements||This is not an internship|
|Recommended optional programme components||None|
|Course availability||The course is available to visiting students|
Phases of drug metabolism. Main reactions of the first and second phase.Cytochromes P450 as the most important enzymes of drug metabolism. Genomics and proteomics of P450. Gene superfamily of P450. Function of P450 in drug metabolism, enzyme induction and inhibition. Gene polymorphism. Drug interactions, types. Clinically relevant pharmacokinetic drug interactions.
|Learning activities and teaching methods|
|Lecture, Dialogic Lecture (Discussion, Dialog, Brainstorming), Work with Text (with Book, Textbook)|
Students learn about the metabolism of the drugs, about cytochromes P450 which are responsible for metabolism of more than three fourth of drugs with known metabolic pathways. Students should be familiar also with the drug interactions at the level of drug metabolism (competition, inhibition or induction of P450 enzymes).
Students should be familiar with the metabolism and interaction of the main groups of drugs.
Completion all of prescribed exams.
|Assessment methods and criteria|
Analysis of Activities ( Technical works), Dialog
Participation in all seminars.
|Study plans that include the course|
|Faculty||Study plan (Version)||Branch of study Category||Recommended year of study||Recommended semester|
|Faculty of Medicine and Dentistry||General Medicine (2011)||Medical sciences||4||Summer|
|Faculty of Medicine and Dentistry||General Medicine (2015)||Medical sciences||4||Summer|
|Faculty of Medicine and Dentistry||General Medicine (2014)||Medical sciences||4||Summer|
|Faculty of Medicine and Dentistry||General Medicine (2012)||Medical sciences||4||Summer|