Course: Structural bioinformatics

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Course title Structural bioinformatics
Course code KBC/PGSB6
Organizational form of instruction Lecture
Level of course Doctoral
Year of study not specified
Semester Winter and summer
Number of ECTS credits 20
Language of instruction Czech, English
Status of course unspecified
Form of instruction Face-to-face
Work placements This is not an internship
Recommended optional programme components None
  • Frébort Ivo, prof. RNDr. CSc., Ph.D.
Course content
Bioinformatics and structural bioinformatics. Principles of protein structure. Principles of structure DNA and RNA. Determination of the structure by crystallography, NMR and electron microscopy. Visualization of molecules, databases and data interpretation. Structural alignments. Identification of structural domains of proteins. Elucidations of protein function from structural data. Protein-protein interactions. Docking of small ligand into protein structures. Homology modeling. Structural genomics.

Learning activities and teaching methods
Dialogic Lecture (Discussion, Dialog, Brainstorming)
  • Preparation for the Exam - 50 hours per semester
Learning outcomes
Obtaining advanced knowledge on the structure of nucleic acids and proteins.
Evaluate particular methods and procedures in structural bioinformatics, explain results.
The course is intended for doctoral students in Biochemistry.

Assessment methods and criteria

The candidate is expected to conduct scientific discussion in broader context of the whole discipline.
Recommended literature
  • Bourne, P.E., Weissig, H. (2003). Structural bioinformatics. Wiley-Liss, Hobojem, NJ, USA.

Study plans that include the course
Faculty Study plan (Version) Branch of study Category Recommended year of study Recommended semester