Course: Clinical Biophysics

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Course title Clinical Biophysics
Course code LBF/VC041
Organizational form of instruction Lecture + Seminar
Level of course Master
Year of study not specified
Semester Winter
Number of ECTS credits 3
Language of instruction Czech
Status of course Compulsory-optional
Form of instruction Face-to-face
Work placements This is not an internship
Recommended optional programme components None
Course availability The course is available to visiting students
  • Kolářová Hana, prof. RNDr. CSc.
  • Doležal Ladislav, Ing. CSc.
  • Bajgar Robert, MUDr. Mgr. Ph.D.
  • Binder Svatopluk, Mgr. Ph.D.
  • Maceček Jaroslav, Mgr. Ph.D.
Course content
Lasers in medicine, microsurgery. Scanning methods for body temperature measurement. Radiation risks and safety. Stochastic and deterministic effects. X-ray diagnostic methods I. Skiagraphy, skiascopy, angiography (AG), digital subtraction angiography (DSA). X-ray diagnostic methods II. Computer tomography (CT), CT angiography (CTA). Radionuclide imaging, positron emission tomography (PET). Pulse wave. Clinical applications of ultrasonics. Photodynamic therapy (PDT). Principal of PDT, types of photodynamic active drugs, sources of radiation. Biological response, methods of cell damage analysing, clinical applications. Nuclear magnetic resonance imaging (MRI). Biophysical principles of non-invasive and invasive therapeutic methods. Hemodialysis, peritoneal dialysis, continual methods, hemoperfusion, plasmapheresis. Electrodiagnostic methods. Presentation of seminar papers.

Learning activities and teaching methods
Lecture, Monologic Lecture(Interpretation, Training), Dialogic Lecture (Discussion, Dialog, Brainstorming)
Learning outcomes
The course offers an overview of modern diagnostic and therapeutic methods such as X-ray diagnostic methods, radionuclide imaging, magnetic resonance imaging, photodynamic therapy, electrodiagnostic methods, ultrasound in medicine and others. Each topic introduces and explains the physical principle of the method and of course its clinical applications. Specially, the emphasis is placed on such methods, which students meet at the clinics of the University Teaching Hospital.
Students will be able to understand the basic physical principles of commonly used diagnostic and therapeutic methods including the data analysis and image processing. They will be able to make right decision and chose adequate instrumental technique to diagnose or treat different kinds of diseases.
Students ought to have fundamental attainments in medical biophysics at a college level.
IN0/VCA12 and MIK/VCA12 and SOL/VCA13 and FAR/VCB11 and IN2/VCB22 and PAT/VCA11 and PFY/VCA11 and PSY/VCA13 and CJA/VCB21
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CJA/VCB31 and KIM/VCB12 and SOL/VCB32

Assessment methods and criteria
Mark, Written exam, Student performance, Seminar Work

100% active attendance at seminars
Recommended literature
  • Studijní materiály k přednáškám (courseware/
  • Bělohlávek, O. a kol. (2004). Positron emission tomography with fluorodeoxyglucose (FDG PET): atlas of examples of clinical use. Praha: Agentura Pankrác.
  • Drastich, A. (2004). Tomografické zobrazovací systémy. Brno: Vysoké učení technické v Brně.
  • Ferda, J., Mírka, H., Baxa, J. (2009). Multidetektorová výpočetní tomografie: technika šetření. Praha: Galén.
  • Hrazdira, I. (2011). Biofyzikální základy ultrasonografie: jak pracovat s ultrazvukovým diagnostickým přístrojem. Olomouc: Univerzita Palackého v Olomouci.
  • Nölting, B. (2005). Methods in Modern Biophysics. Springer.
  • Rosina, J. a kol. (2013). Biofyzika: pro zdravotnické a biomedicínské obory. Praha: Grada.
  • Votrubová, J. a kol. (2009). Klinické PET a PET/CT. Praha: Galén.

Study plans that include the course
Faculty Study plan (Version) Branch of study Category Recommended year of study Recommended semester
Faculty of Medicine and Dentistry General Medicine (2015) Medical sciences 4 Winter
Faculty of Medicine and Dentistry General Medicine (2014) Medical sciences 4 Winter
Faculty of Medicine and Dentistry General Medicine (2011) Medical sciences 4 Winter
Faculty of Medicine and Dentistry General Medicine (2012) Medical sciences 4 Winter