Course: Organic Chemistry 2

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Course title Organic Chemistry 2
Course code OCH/OC2
Organizational form of instruction Lecture + Seminar
Level of course Bachelor
Year of study 2
Semester Winter
Number of ECTS credits 3
Language of instruction Czech
Status of course Compulsory, Compulsory-optional, Optional
Form of instruction Face-to-face
Work placements This is not an internship
Recommended optional programme components None
  • Brulíková Lucie, RNDr. Ph.D.
Course content
1. Summary of OC1. 2. Halogen derivatives. 3. Elimination reactions, mechanism E1, E2, E1cB and their stereochemical course. Substitution versus elimination. Alfa elimination reactions. 4. Hydroxy derivatives - alcohols and phenols. 5. Ethers, structure and nomenclature. Physical properties in comparison with alcohols.Thioles and sulfides. Comparison with the oxygen derivatives. Products of oxidation - sulfinic and sulfonic acids, sulfoxides and sulfones. Sulfonic acids and their derivatives, their preparation and reactivity, application. 6.Inorganic acid esters, their preparation and application. 6. Amino derivatives and nomenclature. The basic chemical properties. Hofmann rearrangement. Reactivity of amines with nitrous acid. Diazotization and diazonium salts, coupling reactions. 7. Quaternary amonium salts. Hofmann elimination. Reactions with phase transfer catalysis. Diazocompounds.Diazoalkanes, diazoesters, diazoketones preparation and reactivity. Arndt-Eistert-Wolf rearrangement. Azides. 8. Nitro compounds. Structure and reactivity. Influence of the nitro group on the carbon skeleton. Preparation of nitro compounds. Ambident ions. Reduction of nitro compounds. Azo, azoxy and hydrazo compounds. Nitriles and isonitriles. Structure and reactivity and preparation. Hydrolysis of nitriles. Isonitrile test. 7. Carbonyl derivatives 1. 8. Carbonyl derivatives 2. 9. Carboxylic acids, their structure, representatives, chemical properties. Influence of the carbon rest on the acidity. Esterification. 10. Function derivatives of carboxylic acids (esters, halogen derivatives, amides, anhydrides). Preparation and comparison of their properties. 11. Carbohydrates (aldoses, ketoses, trioses, tetroses, pentoses, hexoses), nomenclature. Mutarotation and cyclic form. 12. Heterocyclic compounds.

Learning activities and teaching methods
Learning outcomes
Specialized course focusing on the study of properties and reactivity of organic compounds and their synthesis.
Define main concepts, describe main approaches, present system of the organic chemistry

Assessment methods and criteria
Oral exam, Written exam

Credit will be given in case of passing two writting tests during the semester at least 60%. For the exam is student allowed only when successfully gets the credit. The exam consists of written and oral.
Recommended literature
  • Clayden J, Greeves N. Warren S. Organic chemistry.
  • Červinka O., Dědek V., Ferles M. (1969). Organická chemie. SNTL, ALFA Bratislava.
  • Červinka O., Dědek V., Ferles M. (1980). Organická chemie. SNTL Praha.
  • McMurry J. Organická chemie.
  • Slouka J., Fryšová I., Hlaváč J. (2005). Stručný přehled organické chemie ve formě reakčních schemat (1. Uhlovodíky, 2. Halogenderiváty). UP Olomouc.
  • Slouka J., Wiedermannova I. (2003). Průvodce některými úvodními kapitolami organické chemie. UP Olomouc.

Study plans that include the course
Faculty Study plan (Version) Branch of study Category Recommended year of study Recommended semester
Faculty of Science Bioorganic Chemistry and Chemical Biology (2016) Chemistry courses 2 Winter
Faculty of Science Biochemistry (1) Chemistry courses 2 Winter
Faculty of Science Nanomaterial Chemistry (2016) Chemistry courses 2 Winter
Faculty of Science Chemistry (1) Chemistry courses 2 Winter
Faculty of Science Bioinorganic Chemistry (1) Chemistry courses 2 Winter
Faculty of Science Chemistry More Subjects Studium (1) Chemistry courses 2 Winter
Faculty of Science Applied Chemistry (1) Chemistry courses 3 Winter