Course: Pathological Physiology

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Course title Pathological Physiology
Course code PFY/VCB11
Organizational form of instruction Lecture + Exercise
Level of course Master
Year of study not specified
Semester Summer
Number of ECTS credits 10
Language of instruction Czech
Status of course Compulsory
Form of instruction Face-to-face
Work placements This is not an internship
Recommended optional programme components None
Course availability The course is available to visiting students
  • Vítovská Hana, MUDr.
  • Cápec Szergej, Ph.D.
  • Benická Alžběta, MUDr.
  • Navrátilová Zdenka, Mgr. Ph.D.
  • Dostálová Květoslava, doc. MUDr. CSc.
  • Petřek Martin, prof. MUDr. CSc.
Course content
Pathophysioloy of the respiratory system. Blood gasses. Acute respiratory disturbances. Pulmonary embolism. Pulmonary oedema. RDSs. Pathophysiology of kidney. End-stage renal disease. Kidney failure. Nephritic and nephrotic syndromes. Water and salt disturbances. Diabetes mellitus. Acute and chronic complications Acid-base disorders. Disorders of endocrine system. Oedema - local and global. ECG, heart failure, hypertension, acute circulatory failure.

Learning activities and teaching methods
Lecture, Dialogic Lecture (Discussion, Dialog, Brainstorming), Work with Text (with Book, Textbook), Methods of Written Work, Projection (static, dynamic)
Learning outcomes
During the course of study students study common principles of the pathogenesis of the most important disorders of respiratory, cardiovascular, endocrine systems and kidneys, provided with interpretation of typical clinical case studies. Student learn to analyse role of different risk factors in pathogenesis of atherosclerosis, arterial hypertension, bronchial asthma, COPD, diabetes mellitus, kidney failure and other important medical states, comparing common and different pathways in pathogenesis of these states. Etiology, pathogenesis and clinical manifestations of life-threatening states (shock, coma, heart/respiratory/kidney failures) are explained together with main principles of diagnostics, treatment and prophylaxis of the disorders. The students are taught to consider the complex relations between causes, dynamics and progress of diseases and to perceive the integrative essence of medicine.
The students are able to evaluate the complex history and laboratory and clinical data that are required to establish the diagnosis, plan therapy, and/or set preventive measures. The students understand the principles of experimental and clinical research. The students are endowed with the multifaceted theoretical background for subsequent clinical studies as well as evidence-based medicinal practice.
Completion of courses "BIochemistry", "Physiology","Normal Anatomy II" and "Histology and Embryology II".
PFY/VCA11 and NAN/VCB13 and HIE/VCA12 and LCH/VCA20 and FYZ/VCB12

Assessment methods and criteria
Mark, Oral exam, Written exam, Essay

Credit conditions are as follows: 1) Passing of practical exercises with a tolerance of 1 absence without substitution. For each additional absence, justification (e.g. G.P. confirmation) must be provided and the lesson substituted; student can substitute not more than 1/3 of compulsory education course (15th week is reserved for replacements). 2) Credit will be granted upon successful answering 2/3 of questions from the respective term topics in the final test on the computer in the 15th week of the term. 3) For students, who were active during the term and in ongoing tests achieved average score over 2/3 of questions answered*, final test will not be mandatory. 4) There are two possibilities for correction of unsuccessful credit test; after that, at the discretion of the department, opportunity for oral correction with at least two teachers will be considered. *bonification of up to 10% of average score can be earned by presenting a topic recommended by teacher to fellow students.
Recommended literature
  • Vzdělávací portál vytvořený v rámci projektu "Tvorba a ověření e-learningového prostředí pro integraci výuky preklinických a klinických předmětů na LF a FZV UP Olomouc.
  • Nečas E. a kol. (2013). Obecná potologická fyziologie. Praha.
  • Nečas E. a kol.:. (2013). Patologická fyziologie orgánových systémů II.. Karolinum Praha 2013.
  • Nečas E. a kol.:. (2013). Patologická fyziologie orgánových systémů I.. Karolinum Praha 2013.
  • Silbernagl, S., Lang, F., & Jandová, K. (2012). Atlas patofyziologie. Praha: Grada Publishing.

Study plans that include the course
Faculty Study plan (Version) Branch of study Category Recommended year of study Recommended semester
Faculty of Medicine and Dentistry General Medicine (2012) Medical sciences 3 Summer
Faculty of Medicine and Dentistry General Medicine (2014) Medical sciences 3 Summer
Faculty of Medicine and Dentistry General Medicine (2011) Medical sciences 3 Summer